• Ages: 18-75 Years（concluding 18 and 75 Years）;

• Pathologically confirmed resectable or potentially resectable locally advanced gastric/gastroesophageal junction adenocarcinoma (cT3/4aN+M0) ;

• Bone scan should be performed if bone metastasis is suspected. If peritoneal metastasis is suspected, abdominal examination should be performed to exclude distant metastasis；

• ECOG PS 0-1, there was no deterioration within 7 days;

• BMI≥18；

• Has life expectancy of greater than 12 months；

• No prior antitumor therapy (e.g., radiotherapy, chemotherapy, targeted therapy, immunotherapy, etc.)；

• Have measurable lesions (according to RECIST 1.1);

• The main organ functions meet the following criteria: (without blood transfusion or any blood component or cell growth factor within 14 days prior to enrollment):

‣ Absolute Neutrophil Count (ANC)≥1.5×109/L, White Blood Cell≥4.0×109/L；

⁃ Platelet Count of ≥100×109/L；

⁃ Hemoglobin≥90g/L；

⁃ Total Bilirubin (TBIL)≤1.5 x ULN；

⁃ ALT and AST≤2.5 x ULN；

⁃ Urea/Urea Nitrogen（BUN）and Creatinine（Cr）≤1.5×ULN (and creatinine clearance (CCr)≥ 50mL/min);

⁃ Left Ventricular Ejection Fraction (LVEF)≥50%;

⁃ Electrocardiogram (ECG) Corrected QT Interval (QTcF)\<470ms;

⁃ INR≤1.5×ULN，APTT≤1.5×ULN;